Yes — thousands of builders do, with three pieces of discipline. Spray acrylics (low odor, water cleanup) as your default chemistry; use a compressor with a tank and auto shut-off so noise comes in short refill bursts rather than constant drone; and exhaust overspray with a filtered spray booth vented toward a window.
Save lacquers and rattlecan topcoats for a balcony, garage, or a properly vented booth plus an organic-vapor respirator. The overspray you can smell is the overspray you are breathing.
Go deeper in our booths, masks & safety guides.